Best Appetite Suppressant Pills In 2025: Top 5 Strongest Over the Counter (OTC) Hunger Control Supplements for Fastest Weight Loss

One of the most challenging aspects of losing weight is controlling what you eat. Hunger is a human instinct, and saying no to your favorite carb- and calorie-heavy meals may feel even more difficult than working out every day.

That's where appetite suppressants come in.

Appetite suppressants are natural, safe supplements that work to suppress your appetite, helping you control your food intake as a result. These pills contain ingredients ranging from green coffee beans to caffeine to Vitamin B6, and each of their components works together to help you feel fuller longer.

While some appetite suppressants are safe and effective, others contain harmful ingredients that can produce adverse side effects. To help you distinguish which supplements are right for you, we have reviewed the top appetite suppressant supplements on the market.

Top 5 Best Appetite Suppressant Pills of 2025

#1) PhenQ: Best Overall and Highest Quality

The best appetite suppressants do more than just reduce your appetite—they also help you lose weight in other ways. PhenQ is our top appetite suppressant overall because of its quality, safe ingredients, and five-step approach to losing weight.

PhenQ is a natural supplement that has benefitted over 190,000 customers in just a few years. This supplement takes a multi-action approach to weight loss by helping you:

Burn fat
Stop fat production
Suppress your appetite
Boost your energy levels
Improve your mood

Combining these benefits into one pill allows you to get rid of the other weight loss supplements in your cabinet and focus on one daily capsule.

PhenQ's primary ingredient is α-Lacys Reset, an antioxidant synergy that contains alpha-lipoic acid, cysteine base, and magnesium. This combination regulates the production of free radicals in your cells, accelerates your metabolism, and stimulates your calorie-burning processes.

Increasing your metabolism boosts thermogenesis, or your body's heat production process. Turning up your natural heat processes helps you burn fat and calories faster, even while resting. Clinical studies have found that people taking α-Lacys Reset lost an average of 7.24% body fat and 3.44% body weight. They also increased 3.80% muscle mass.

L-carnitine is a fat burner that can help you lose weight when you take it long-term. PhenQ contains the recommended dose of this substance to help your body turn its stored fat into energy. The product combines the powerful effects of α-Lacys Reset and L-carnitine with other natural fat burners to optimize your weight loss.

PhenQ contains the following ingredients:

α-Lacys Reset
Capsimax powder
Chromium picolinate
Caffeine
Nopal
L-carnitine fumarate

The supplement's creators recommend taking one pill with breakfast and one with lunch each day. Because PhenQ contains caffeine, you may want to cut down your coffee and tea intake while taking PhenQ.

Overall, PhenQ can be a life-changer for anyone trying to reduce their food intake and burn calories faster.

Boost metabolism, curb cravings, and shrink fat cells
Very effective for appetite suppression
100% all natural ingredients
Boosts energy levels and improves mood
60-day money back guarantee

#2) PhenGold: Best Appetite Suppressant For Women

PhenGold is the top-rated appetite suppressant for women looking to lose weight and reduce hunger cravings.

PhenGold is a natural supplement designed to help women burn fat and achieve their weight loss goals. This powerful, effective formula can help women achieve a firmer, more toned physique alongside an exercise regimen.

PhenGold can produce the following benefits:

Suppress cravings
Reduce calorie intake
Support health fat metabolism
Improve your energy levels
Boost your focus

One of PhenGold's most potent ingredients is glucomannan, a natural dietary fiber that swells in your stomach. Glucomannan absorbs liquid better than other fibers, allowing it to take up more space in your stomach and help you feel full. This fiber also delays stomach emptying, promoting satiety.

PhenGold also contains choline, a nutrient that helps control cholesterol and fat build-up in your body. This ingredient can promote normal fat metabolism and healthy homocysteine metabolism, both of which help you lose weight.

PhenGold's formula contains the following ingredients:

Green tea extract
L-Tyrosine
Rhodiola SP
Green coffee
Green Coffee
Bioperine
Magnesium Stearate
L-tyrosine
DMAE Bitarate
Cayenne powder

Each of these twelve ingredients aids weight loss differently, creating a well-rounded, effective formula.

PhenGold's creators recommend taking three capsules throughout the day. To see the best results, you should take each dose at least thirty minutes before a meal with a full 8 oz of water.

PhenGold's targeted formula, appetite-suppressing ingredients, and metabolism-boosting qualities make this supplement ideal for women trying to lose excess weight.

Best appetite suppressant for women
Burn stubborn fat and finally reach your body goals
All natural ingredients including green coffee bean extract
Provides a clean energy boost
Boosts metabolism and ignites your body’s fat burning process

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#3) PrimeShred: Natural Hunger Suppressant For Men

Just as women need their own targeted appetite suppressants, men also need supplements that focus on their specific weight loss processes. PrimeShred is a natural weight loss supplement that has helped MMA fighters and boxers burn fat quickly to meet weigh-in goals.

While PrimeShred focuses more on fat burning, the supplement also contains appetite-suppressing ingredients contributing to holistic weight loss. Overall, this fat burner can produce the following benefits:

Increase your metabolism
Suppress your appetite
Reduce cravings
Boost your energy levels

PrimeShred assists fat loss by turning off your body's Alpha-2 receptor, the receptor that tells your body to store fat. Green tea extract, one of the supplement's natural ingredients, switches off this receptor and triggers your fat-burning processes.

PrimeShred also includes cayenne pepper seeds, which contain capsaicin, a compound that acts as a potent thermogenic. Taking capsaicin can reduce hunger pangs and help you burn fat faster.

Additionally, the PrimeShred formula includes glucomannan, the dietary fiber that swells in your stomach and improves satiety. Taking PrimeShred throughout the day can help you feel full longer and reduce your calorie intake, helping you reach your weight loss goals.

Altogether, PrimeShred's formula contains:

Green Tea Extract
Caffeine Anhydrous
Vitamin B Complex
Rhodiola Rosea Root
Bioperine
Green Coffee Bean
DMAE
L-Tyrosine
L-Theanine
Cayenne Pepper Seeds

The supplement's creators recommend taking one capsule three times per day. You should split up your dose by taking one in the morning, one before lunch and one before dinner. Taking three equal amounts of this fat burner allows your body to continue burning fat longer and ensures that you fully absorb each dose.

All in all, PrimeShred is an effective weight loss supplement for men looking to cut their cravings and boost their metabolism.

Powerful fat burning supplement that suppresses appetite and promotes weight loss
Endorsed by MMA fighters and professional athletes
100% natural ingredients including green tea extract
Good appetite suppressant supplement for men

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#4) TrimTone: Best Value

TrimTone is another natural appetite suppressant for women that includes powerful ingredients in an effective formula. If you're on a budget, you'll appreciate the value for your dollar that you can receive when purchasing TrimTone supplements.

TrimTone is a 100% natural dietary supplement that targets several aspects of weight loss. Taking TrimTone can help you:

Burn stubborn fat
Reduce cravings
Achieve your fitness goals
Feel more confident in your body

One of TrimTone's primary ingredients is caffeine, which increases thermogenesis to promote fat-burning processes. Caffeine is also a performance enhancer and stimulant, so taking TrimTone can increase your energy levels and help you get through a workout.

TrimTone contains straight-up caffeine along with ingredients like green coffee and green tea that have trace amounts of the substance. Like a few other supplements on our list, TrimTone also contains the dietary fiber glucomannan. Taking glucomannan regularly can help suppress appetite and cravings, encourage you to stick to your diet, and help you feel full.

TrimTone's formula is simple, and the creators stress that it only contains natural, effective ingredients with no unnecessary fillers. This formula includes:

Caffeine
Green coffee
Green tea extract
Grains of paradise
Glucomannan

The TrimTone creators recommend taking one capsule per day before breakfast. Because the daily dosage is just one pill, you do not need to spend hundreds of dollars on a monthly supply—purchasing an affordable 30-count bottle will last you a full month. TrimTone also offers promotions and discounts regularly to reduce your overall costs further.

Pairing TrimTone with diet and exercise can help you achieve your weight loss goals faster and feel more confident in your own skin. Overall, TrimTone is an effective supplement for anyone looking for an affordable weight loss solution.

High-quality formula designed specifically for women
Burns fat, reduces appetite, and boost metabolism
Helps your body burn more calories throughout the day, even while resting
Suppress appetite, reduce cravings, and reach your weight loss goals faster
Money Back guarantee and free delivery

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#5) Zotrim: Top-Rated Herbal Appetite Suppressant

If you prefer herbal ingredients to minerals and nutrients, you will appreciate Zotrim's 100% herbal appetite suppressant formula.

Zotrim is an appetite suppressant that can help you control your hunger and reduce food cravings. This clinically proven formula outperformed prescription drugs in research trials, and the creators found that Zotrim leads to better and faster weight loss even without diet.

Taking Zotrim can produce the following benefits for your body:

Craving management
Suppresses appetite
Lasting weight loss

Zotrim helps curb hunger by containing several ingredients that have high caffeine levels. If you've ever drunk a large cup of coffee quickly, you know that caffeine can reduce your hunger and help you feel full. Caffeine also boosts your energy levels, delays stomach emptying, and impacts appetite hormones.

Damiana, another one of Zotrim's herbal ingredients, has mood-enhancing properties. Weight loss can often affect your mood, and taking dietary supplements containing damiana can counteract those adverse effects to help you regulate your mood and stick to your diet.

While every appetite suppressant on our list is natural, Zotrim takes its formula a step further by only including herbal extracts and vitamins. This supplement contains:

Yerba Maté – leaf extract
Guarana – seed extract
Damiana – leaf extract
Caffeine
Vitamin B3
Vitamin B6

Zotrim's creators consulted an international team of medical researchers and spent years designing and perfecting the Zotrim formula. As a result, you can feel confident that the supplement's five herbal ingredients are safe and effective to help you lose weight.

Zotrim's creators recommend taking two to three Zotrim capsules with water before each meal to see the best results.

Overall, Zotrim is an effective appetite suppressant for anyone who wants to stick to herbal-only ingredients.

Controls hunger and food cravings for significant weight loss
Contains herbal ingredients that are backed by clinical studies
Performs better than some prescription weight loss drugs in trials
Vegan friendly
100-day weight loss guarantee

Click Here for the Lowest Price on Zotrim

How We Ranked The Top Appetite Suppressant Supplements

Dozens of appetite suppressant supplements exist across the Internet, and the everyday consumer may have trouble determining which ones are reliable and which are unsafe or ineffective. As we searched for the strongest appetite suppressants on the market, we reviewed the following characteristics in each supplement:

– Ingredients

A supplement's ingredients are some of the most important factors relating to its effectiveness and quality. The best appetite suppressants list their ingredients on their websites instead of containing secret, “proprietary” formulas. These dietary supplements also explain why they included each ingredient and specify how each component contributes to weight loss and appetite suppression.

As you can see from our list, some effective appetite suppressant pills contain a few ingredients, while others have ten or twelve. However, the number of ingredients in a supplement is not as important as those ingredients' quality. Each of the supplements on our list contains high-quality, effective components.

– Dosage

Dosage is another crucial factor to consider when determining a supplement's quality. If an appetite suppressant has high-quality, effective ingredients but only includes small dosages of each, the overall formula will probably not be very beneficial.

Along with considering each ingredient's dosage, you should also consider how many capsules you are supposed to take each day. Some suppressants work best when you take six or more capsules a day, while others consolidate their doses into a single pill. Our list contains supplements on both sides of the spectrum, and the one you choose ultimately comes down to personal preference.

– Customer Reviews

Customer reviews can give you a wealth of information about a supplement's quality, potency, effectiveness, and side effects. Many supplement companies include positive customer reviews on their websites, but we searched outside of these reviews to find unbiased, comprehensive opinions from real customers.

Each of the supplements on our list has more positive reviews than negative ones.

– Price

Appetite-suppressant supplements can come in various price ranges, and price does not always indicate quality. Each of the supplements on our list is affordable while still meeting high quality, dosage, and design standards.

– Safety

Perhaps the most crucial quality to look for in an appetite suppressant is safety. If a dietary supplement delivers noticeable weight loss results in an unsafe way, it could produce more harm than good.

Natural supplements tend to be safe overall because they do not contain any harmful additives or chemicals. However, we verified that each appetite suppressant on our list meets the highest safety standards.

How Do Appetite Suppressant Pills Reduce Cravings?

Appetite suppressant supplements contain several ingredients that work to reduce appetite and cravings in a few different ways.

Some suppressants contain dietary fiber, such as glucomannan, that absorbs water easily and takes up space in your stomach. Taking pills that contain dietary fiber can help you feel fuller longer, reducing your desire to eat more food. Fiber can also delay stomach emptying, which contributes to your satiety.

Next, some appetite suppressant supplements include stimulants such as caffeine, along with ingredients that contain caffeine, like tea or coffee beans. Caffeine can reduce feelings of hunger as it works its way through your body. Some people try to drink more coffee or black tea to lose weight, but taking supplements that contain caffeine is an easier way to regulate your caffeine intake.

A few of the weight loss suppressants on our list also target weight loss in other ways. Some contain ingredients that stimulate thermogenesis, others block receptors that inhibit fat loss, and some include vitamins that support your regular bodily functions.

If you're wondering how a specific supplement reduces your appetite and controls cravings, you can read more about its formula on its website.

Natural Ingredients That Control Hunger

The natural appetite suppressant supplements on our list contain pure ingredients that you could find in nature instead of medications or chemicals. Let's take a closer look at several of the most potent ingredients in these appetite suppressant supplements.

1. Conjugated Linoleic Acid

Conjugated linoleic acid (CLA) is an acid that you could typically find in dairy or meat. Studies have shown that CLA can help you reduce food intake, increase fat-burning processes, and even inhibit fat production in your body.

2. Bitter Orange (Synephrine)

Bitter orange oil comes from a tree native to Asia and contains the active ingredient synephrine. This ingredient includes several chemicals that can affect the central nervous system and promote weight loss. However, too much bitter orange can lead to high blood pressure, so most diet pills only contain trace amounts of the substance.

3. Garcinia Cambogia

Garcinia cambogia, also known as the Malabar tamarind, is a tropical fruit that contains the active ingredient hydroxycitric acid (HCA). Researchers believe that HCA blocks a fat-producing enzyme in your body and raises your serotonin levels, which may reduce appetite and control hunger.

Other studies have suggested that Garcinia cambogia may improve your cholesterol, so you should avoid this ingredient if you already take prescription medication for cholesterol.

4. Glucomannan

Glucomannan is a dietary fiber that comes from the konjac plant's roots, also known as the elephant yam. Many kinds of pasta and bread products contain glucomannan as an added ingredient.

Researchers believe that glucomannan can help people lose weight because it is low in calories but takes up room in your stomach, helping you feel fuller than you are.

Glucomannan is even denser than other forms of dietary fiber, allowing it to absorb more water and help you reduce your food intake.

Because it is a soluble fiber, glucomannan also reduces your body's absorption of fat and protein.

5. Caralluma Fimbriata

Caralluma fimbriata is an edible cactus that hails from India. Research has shown that this plant can reduce appetite and help you eat less food at each meal. More research is necessary to determine other health benefits that may result from taking Caralluma fimbriata.

6. Green Coffee Bean Extract

Green coffee bean contains chlorogenic acid, a substance that can help reduce hunger pangs, inhibit fat production, and prevent weight gain. Roasting coffee beans reduces their chlorogenic acid content, so drinking coffee will not produce the same effects as taking diet pills that contain green coffee extract.

7. Green Tea Extract

Green tea extract, or green tea's concentrated form, is high in antioxidants and can lead to numerous health benefits. Studies have shown that this extract can enhance thermogenesis, allowing your body to burn more calories and reduce your body mass. Its caffeine content can also boost your energy and promote appetite suppression.

8. Forskolin

Forskolin is an extract from the Coleus forskohlii plant. People have used this extract for several hundred years to treat a wide range of maladies. However, today, many weight loss pills include the extract in their formulas to help reduce hunger and boost metabolism.

One study suggests that forskolin may raise testosterone levels in men, allowing men to lose fat faster and gain muscle.

9. Yerba Mate

Yerba mate is a South American drink that may help you lose excess body fat and boost your metabolism. One study showed that taking 3 g of yerba mate each day can reduce your waist-to-hip ratio by an average of 2%.

Yerba mate can also produce other health benefits, such as boosting your energy levels, enhancing physical performance, and protecting against infections.

10. Chromium Picolinate

Chromium picolinate is a mineral that may improve nutrient metabolism and promote fat loss. Research has shown that this mineral may also reduce hunger and help you control cravings, making it easier to stick to a calorie deficit.

Other Ways to Suppress Your Appetite

If you'd prefer not to take a diet pill for losing weight, you may want to try some other natural methods of suppressing your appetite. Here are a few ways to reduce cravings and eat less food without spending money on any hunger-suppressing products.

Eat More Protein

Eating high-protein foods can help you stay fuller longer and reduce your feelings of hunger. Increased protein intake can also boost your metabolism, allowing your body to burn fat and calories faster and give you the energy you need to stay active.

A few protein-rich foods include:

– Lean meats

– Dairy products

– Eggs

– Seafood

– Nuts

Centering your meals around one main protein-rich food is a practical way to manage your appetite between meals.

Eat Fiber-Rich Foods

Fiber-rich foods can also keep you full in between meals. As we mentioned earlier, soluble fibers absorb water, causing them to swell once they reach your stomach. Eating high fiber foods convinces your stomach that you have eaten more than you have, curbing your hunger in the process.

Drink More Water

Filling up on water is another practical way to suppress your appetite naturally. When you drink a glass of water before your meal, your stomach will feel full, and your metabolism will jump-start. Staying hydrated can also help you maintain high energy levels, keep your skin clear, and produce several other benefits for your body.

Eat Spicy Foods

A few of the appetite suppressing supplements on our list include cayenne or another spicy pepper in their formulas. Spicy foods contain capsaicin, an active compound that can help you lose weight and suppress your hunger.

Eating a food containing capsaicin can boost your metabolic rate and trigger thermogenesis in your body, producing the “hot” feeling you notice when you eat something spicy. If you enjoy spicy foods, adding some spice to your meals or snacking on hot peppers could suppress your hunger between meals.

Drink Coffee

As we mentioned earlier, caffeine can suppress your appetite and give you the energy to complete workouts every day. If you don't already drink coffee in the morning, adding a black cup of joe to your daily routine could help you keep your appetite in check.

Over-the-Counter Appetite Suppressants vs. Prescription

If you've done much research into weight loss pills, you probably know that you can purchase prescription appetite-suppressing pills along with over-the-counter ones.

Prescription appetite pills tend to contain more potent ingredients than ones you could buy in-store or online. These pills target your neurotransmitters and stimulate your hypothalamus gland, telling your brain not to eat rather than suppressing your appetite naturally. A few popular prescription appetite suppressants include Adipex, Didrex, and Bontril.

Your doctor may prescribe a prescription appetite suppressant if you have already tried limiting your caloric intake on your own without success. Many people turn to the appetite pills on our list as a first solution before talking to a doctor or trying a more regulated diet and fitness regimen.

Do Weight Loss Supplements Have Any Side Effects?

Appetite suppressants typically do not produce any adverse side effects. Their ingredients are safe and come from nature, and you do not need a doctor's approval to purchase or begin taking them. However, you should only take each supplement's recommended dose and follow any additional instructions from the manufacturers.

If customers do experience side effects, they are typically mild and short-lasting. Some of the most common side effects from these suppressant pills include:

Diarrhea
Nausea
Gas

If you experience any of these side effects, you should stop taking the supplement immediately and talk to your doctor. However, you will only experience positive results when taking these appetite suppressant and fat burner pills in most cases.

Dietary supplements typically are not FDA-approved, meaning the FDA has not verified any of their claims since the FDA does not regulate supplements. You should use discernment to determine if a supplement is safe for consumption.

Do Appetite Suppressants Really Help You Lose Weight?

Make no mistake—appetite suppressants are not magical solutions that will instantly make you drop 30 pounds. Taking these pills by themselves will only produce mild results by helping you eat less food, increase your metabolic rate, and stick to your diet.

However, pairing suppressant pills with a healthy diet and regular exercise routine can help you burn excess fat and meet your weight goals faster. If you've had trouble slimming down on your own, taking an appetite suppressant supplement could be the boost you need to achieve your goal weight.

Who Should Use Appetite Suppressants?

We recommend only trying an appetite suppressant supplement if you have already attempted to lose weight on your own. As we mentioned above, suppressant pills only do some of the work for you, and the majority of your fat loss will come from eating well and exercising often.

Healthy adults who are looking to reduce the amount of food they eat each day can benefit the most from taking an appetite suppressant supplement. If you have any underlying health conditions or are taking any other medications to assist your diet, you should talk to your doctor before you use appetite suppressants.

Similarly, if you are allergic to any ingredients in an appetite suppressant, you should refrain from taking it and find a safer alternative.

How Much Do Appetite Suppressants Cost?

Appetite-suppressant products come in various price ranges. The following factors can affect price:

Dosage
The number of capsules in each bottle
The product's ingredients
The sales method (online, in-store)

Typically, a 30-day supply will cost you anywhere from $40 to $100, but you can often receive a discount if you order more than one bottle at a time.

Final Thoughts – Are Appetite Suppressants Right For You?

If you've struggled to lose stubborn weight on your own, an appetite suppressant could be the perfect solution to help you achieve your health and fitness goals.

Because these products contain only safe ingredients that you could find in nature, you don't have to worry about them producing any adverse side effects or hindering your healthy habits.

Pairing one of the best appetite suppressant products on our list with a low-calorie diet and frequent exercise could give you the boost you need to achieve your goal weight and feel confident in your own skin.